Danazol is a synthetic steroid derived from ethisterone (ethinyl testosterone). Danazol is antiestrogenic and weakly androgenic. Danazol is used in the treatment of endometriosis, unless the process has advanced to the stage of surgical correction. Danazol also is used in the palliative treatment of fibrocystic breast disease. Hereditary angioedema in both males and females also has been successfully treated with danazol. Frequency of attacks can be limited by careful dose reduction after the initial response has been achieved. Danazol was approved by the FDA in 1976.
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